5 every 8 to 12 hours; titrate as needed and tolerated up to 9 mg every 8 to 12 hours Because tolerance to nitroglycerin may develop if plasma levels are maintained continuously, a nitrate-free interval of 10 to 12 hours per day may be appropriate during chronic prophylaxis of angina pectoris. ,
5 every 8 to 12 hours; titrate as needed and tolerated up to 9 mg every 8 to 12 hours Because tolerance to nitroglycerin may develop if plasma levels are maintained continuously, a nitrate-free interval of 10 to 12 hours per day may be appropriate during chronic prophylaxis of angina pectoris. ,